PUBLICATIONS

Recent Publications

Griffin, M. E.; Sorum, A. W.; Miller, G. M.; Goddard, W. A. III.; Hsieh-Wilson, L. C. “Sulfated Glycans Engage the Ang/Tie Pathway to Regulate Vascular Development and Homeostasis,” Nature Chem. Biol. 2020, in press. https://doi.org/10.1038/s41589-020-00657-7 

Joffrin, A. M.; Hsieh-Wilson, L. C. “Photoaffinity Probes for the Identification of Sequence-Specific Glycosaminoglycan-Binding Proteins,” J. Am. Chem. Soc. 2020, 142, 13672-13676. PMID: 32786811. https://doi.org/10.1021/jacs.0c06046 

Liu, L. C.; Wang, Y. L.; Lin, P. L.; Zhang, X.; Cheng, W. C.; Liu, S. H.; Chen, C. J.; Hung, Y.; Jan, C. I.; Chang, L. C.; Qi, X.; Hsieh-Wilson, L. C.; Wang, S. C. “Long Non-Coding RNA HOTAIR Promotes Invasion of Breast Cancer Cells Through Chondroitin Sulfotransferase CHST15.” Int. J. Cancer 2019, 145, 2475-2487. PMID: 30963568; https://doi.org/10.1002/ijc.32319 

Li, X.; Zhu, Q.; Shi, X.; Cheng, Y.; Li, X.; Xu, H.; Duan, X.; Hsieh-Wilson, L. C.; Chu, J.; Pelletier, J.; Ni, M.; Zheng, Z.; Li, S.; Yi, W. “O-GlcNAcylation of Core Components of the Translation Initiation Machinery Regulates Protein Synthesis,” Proc. Natl. Acad. Sci U.S.A. 2019, 116, 7857–7866. PMID: 30940748; https://doi.org/10.1073/pnas.1813026116 

Pawar, Nitin J.; Wang, Lei; Higo, Takuya; Bhattacharya, Chandrabali; Kancharla, Pavan K.; Zhang, Fuming; Baryal, Kedar; Huo, Chang-Xin; Liu, Jian Jian; Linhardt, Robert J.; Huang, Xuefei Xuefei; Hsieh-Wilson, Linda Carol, "Expedient Synthesis of Core Disaccharide Building Blocks from Natural Polysaccharides for Heparan Sulfate Oligosaccharide Assembly” Angewandte Chemie International Edition 2019 DOI: 10.1002/anie.201908805

Li, J.; Li, Z.; Duan, X.; Qin, K.; Dang, L.; Sun, S.; Cai, L.; Hsieh-Wilson, L. C.; Wu, L.; Yi, W. “An Isotope-Coded Photocleavable Probe for Quantitative Profiling of Protein O-GlcNAcylation.” ACS Chem Biol. 2019, 14, 4–10. PMID: 30620550; https://doi.org/10.1021/acschembio.8b01052 

Darabedian, D.; Thompson, J. W.; Chuh, K. N.; Hsieh-Wilson, L. C.; Pratt, M.R. “Optimization of Chemoenzymatic Mass Tagging by Strain-Promoted Cycloaddition (SPAAC) for the Determination of O-GlcNAc Stoichiometry by Western Blotting.” Biochemistry, 2018, 57, 5769–5774. PMCID: PMC6211186; https://doi.org/10.1074/jbc.RA117.000378 

Stopschinski, B. E.; Holmes, B. B.; Miller, G. M.; Manon, V. A.; Vaquer-Alicea, J.; Prueitt, W. L.; Hsieh-Wilson, L. C.; Diamond, M. I. “Specific Glycosaminoglycan chain length and Sulfation Patterns are Required for Cell Uptake of Tau versus a-synuclein and b-Amyloid,” J. Biol. Chem. 2018, 293, 10826–10840. PMCID: PMC6036193. 

Rauch, J. N.; Chen, J. J.; Sorum, A.; Miller, G. M.; Sharf, T.; See, S. K.; Hsieh-Wilson, L. C.; Kampmann, M.; Kosik, K. S. “Tau Internalization is Regulated by 6-O-Sulfation on Heparan Sulfate Proteoglycans (HSPGs),” Sci. Rep. 2018, 23, 6382. PMCID: PMC5913225; https://doi.org/10.1038/s41598-018-24904-z 

Matho, M. H.; Schlossman, A.; Gilchuk, I. M.; Miller, G.; Mikulski, Z.; Hupfer, M.; Wang, J.; Bitra, A.; Meng, X.; Xiang, Y.; Kaever, T.; Doukov, T.; Ley, K; Crotty, S.; Peters, B.; Hsieh-Wilson, L. C.; Crowe, J. E. Jr.; Zajonc, D. M. “Structure-Function Characterization of Three Human Antibodies Targeting the Vaccinia Virus Adhesion Molecule D8,” J. Biol. Chem. 2018, 293, 390–401. PMCID: PMC5766908; https://doi.org/10.1074/jbc.M117.814541 

Thompson, J. W.; Griffin, M. E.; Hsieh-Wilson, L. C. “Methods for the Detection, Study, and Dynamic Profiling of O-GlcNAc Glycosylation,” Methods Enzymol., 2018, 598, 101–135. PMCID: PMC5886303; https://doi.org/10.1016/bs.mie.2017.06.009 

Hsieh-Wilson, Linda C. "A Molecular Window into the Brain: Special Issue on Molecules and the Brain" Biochemistry 2018 57 (27), 3989-3990 DOI: 10.1021/acs.biochem.8b00689

Thompson, John W.; Sorum, Alexander W.; Hsieh-Wilson, Linda C. "Deciphering the Functions of O-GlcNAc Glycosylation in the Brain: The Role of Site-Specific Quantitative O-GlcNAcomics" Biochemistry 2018 57 (27), 4010-4018 DOI: 10.1021/acs.biochem.8b00516

Griffith, A. R..; Rogers, C. J.; Miller, G. M.; Abrol, R.; Hsieh-Wilson, L. C.; Goddard, W. A. III. “Predicting Glycosaminoglycan-Surface Protein Interactions: Implications for Studying Axonal Growth,” Proc. Natl. Acad. Sci. U.S.A. 2017, 114, 13697–13702. PMCID: PMC5748211; https://doi.org/10.1073/pnas.1715093115 

Cheung, S. T.; Miller, M. S.; Pacoma, R.; Roland, J.; Liu, J.; Schumacher, A. M.; Hsieh-ˇWilson, L. C. “Discovery of a Small-ˇMolecule Modulator of Glycosaminoglycan Sulfation,” ACS Chem Biol. 2017, 12, 3126-3133.

Wang AC, Jensen EH, Rexach JE, Vinters HV, Hsieh-Wilson LC. "Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration." Proceedings of the National Academy of Sciences. 2016 Dec 27;113(52):15120-5.

Griffin ME, Hsieh-Wilson, LC. “Glycan engineering for cell and developmental biology.” Cell Chem Biol. 2016, 23(1):108-121.

Griffin ME, Jensen EH, Mason DE, Jenkins CL, Stone SE, Peters EC, Hsieh-Wilson LC. “Comprehensive mapping of O-GlcNAc modification sites using a chemically cleavable tag.” Mol Biosyst. 2016, 12(6): 1756-1759.

Miller, G. M.; Hsieh-Wilson, L. C.; "Sugar-dependent modulation of neuronal development, regeneration, and plasticity by chondroitin sulfate proteoglycans," Experimental Neurology. 2015.

Pulsipher A.; Griffin M. E.;  Stone S. E.; Hsieh-Wilson L. C.; "Long-lived engineering of glycans to direct stem cell fate." Angew Chem Int Ed Engl. 2015, 54, 1466-1470.

Matho M. H.; de Val N.; Miller G. M.; Brown J.; Schlossman A.; Meng X.; Crotty S.; Peters B.; Xiang Y.; Hsieh-Wilson L. C.; Ward A. B.; Zajonc D. M.; "Murine anti-vaccinia virus D8 antibodies target different epitopes and differ in their ability to block D8 binding to CS-E," PLoS Pathog. 2014, 10, e1004495.

Wibowo A.; Peters E. C.; Hsieh-Wilson L. C.; "Photoactivatable glycopolymers for the proteome-wide identification of fucose-α(1-2)-galactose binding proteins," J. Am. Chem. Soc. 2014, 136, 9528-9531.

Pulsipher, A.; Griffin, M. E.; Stone, S. E.; Brown, J. M.; Hsieh-Wilson, L. C. "Directing Neuronal Signaling through Cell-Surface Glycan Engineering," J. Am. Chem. Soc. 2014, 136, 6794-6797.

Hsieh-Wilson, L. C.; Griffin, M. E. "Improving Biologic Drugs via Total Chemical Synthesis," Science 2013, 342, 1332-1333.

Clark, P. M.; Rexach, J. E.; Hsieh-Wilson, L. C. "Visualization of O-GlcNAc Glycosylation Stoichiometry and Dynamics using Resolvable Poly(ethylene glycol) Mass Tags,"  Curr. Protocols Chem. Biol. 2013, 5, 281-302.

Griffin, M. E.; Hsieh-Wilson, L. C. "Synthetic Probes of Glycosaminoglycan Function," Curr. Op. Chem. Biol. 2013, 17, 1014-1022.

Oh, Y. I.; Sheng, G.; Chang, S.-K.; Hsieh-Wilson, L. C. "Tailored Glycopolymers as Anticoagulant Heparin Mimetics," Angew. Chem. Int. Ed.  2013, 52, 11796-11799.

Sheng, G.; Oh, Y. I.; Chang, S.-K.; Hsieh-Wilson, L. C. "Tunable Heparan Sulfate Mimetics for Modulating Chemokine Activity," J. Am. Chem. Soc. 2013, 135, 10898-10901.

Dick, G.; Tan, C. l.; Alves, J. N.; Ehlert, E.; Miller, G.; Hsieh-Wilson, L. C.; Sugahara, K.; Oosterhof, A.; van Kuppevelt, T. H.; Verhaagen, J.; Fawcett, J. W.; Kwok, J. C. F. "Semaphorin 3A Binds to the Perineuronal Nets via Chondroitin Sulfate Type E (CS-E) Motifs in Rodent Brains," J. Biol. Chem. 2013, 288, 27384-27395.

Ramakrishnan, P.; Clark, P. M.; Mason, D. E.; Peters, E. C.; Hsieh-Wilson, L. C.; Baltimore, D. "Activation of the Transcriptional Function of the NF-kB Protein c-Rel by O-GlcNAc Glycosylation," Science Signaling, 2013, 6 ra75.

Yi, W; Clark, P. M.; Mason, D. E.; Keenan, M. C.; Hill. C.; Goddard, W. A., III; Peters, E. C.; Driggers, E. M.; Hsieh-Wilson, L. C. "Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism," Science 2012, 337, 975–980.
Featured in:
Mattaini, K. R.; Vander Heiden, M. G. "Glycosylation to Adapt to Stress," Science 2012, 337, 925–926.
Borman, S. "Glycosylation Linked to Cancer," Chem. Eng. News 2012, 90, 9.
Goodman, C. "A GlcNAc Switch," Nat. Chem. Biol. 2012, 8, 809.
Ray, L. B. "Metabolic Sensor," Sci. Signal. 2012, 5, ec225.

Chaubard, J.-L.; Krishnamurthy, C.; Yi, W.; Smith, D.; Hsieh-Wilson, L. C. "Chemoenzymatic Probes for Detecting and Imaging Fucose-α(1-2)-Galactose Glycan Biomarkers," J. Am. Chem. Soc. 2012, 134, 4489–4492.

Brown, J. M.; Xia, J.; BinQuan, Z.; Cho, K.-S.; Rogers, C. J.; Gama, C. I.; Rawat, M.; Tully, S. E.; Uetani, N.; Mason, D.; Tremblay, M. L.; Peters, E. C.; Habuchi, O.; Chen, D. F.; Hsieh-Wilson, L. C. "A Sulfated Carbohydrate Epitope Inhibits Axon Regeneration After Injury," Proc. Natl. Acad. Sci. U. S. A. 2012, 109, 4768–4773.

Rexach, J. E.; Clark, P. M.; Mason, D. E.; Neve, R. L.; Peters, E. C.; Hsieh-Wilson, L. C. "Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation," Nature Chem. Biol. 2012, 8, 253–261.

Rogers, C. J.; Hsieh-Wilson, L. C. "Microarray method for the rapid detection of glycosaminoglycan-protein interactions," Carbohydrate Microarrays: Methods and Protocols, Methods in Molecular Biology 2012, 808, 321–336.

Rogers, C. J.; Clark, P. M.; Tully, S. E.; Abrol, R.; Garcia, K. C.; Goddard, W. A., III; Hsieh-Wilson, L. C. "Elucidating glycosaminoglycan-protein-protein interactions using carbohydrate microarray and computational approaches," Proc. Natl. Acad. Sci. U. S. A. 2011, 108, 9747–9752.

Lee, S.-G.; Brown, J. M.; Rogers, C. J.; Matson, J. B.; Krishnamurthy, C.; Rawat, Manish; Hsieh-Wilson, L. C. "End-functionalized glycopolymers as mimetics of chondroitin sulfate proteoglycans," Chem. Sci. 2010, 1, 322–325.

Rexach, J. E.; Rogers, C. J.; Yu, S.-H.; Tao, J.; Sun, Y.; Hsieh-Wilson, L. C. "Quantification of O-Glycosylation Stoichiometry and Dynamics using Resolvable Mass Tags," Nature Chem. Biol. 2010, 6, 645–651. Featured in Nature Chem. Biol. 2010, 6, 634–635.

Murrey, H. E.; Ficarro, S. B.; Krishnamurthy, C.; Domino, S. E.; Peters, E. C.; Hsieh-Wilson, L. C. "Identification of the Plasticity-Relevant Fucose-α(1-2)-Galactose Proteome from Mouse Olfactory Bulb," Biochemistry 2009, 48, 7261–7270.

Wang, Z.; Park, K.; Comer F.; Hsieh-Wilson, L. C.; Saudek, C. D., Hart, G. W. "Site-Specific GlcNAcylation of Human Erythrocyte Proteins: Potential Biomarker(s) for Diabetes Mellitus," Diabetes 2009, 58, 309–317.

Clark, P. M.; Dweck, J. F.; Mason, D.; Hart, C.; Buck, S. B.; Peters, E. C.; Agnew, B. J.; Hsieh-Wilson, L. C. "Direct In-Gel Fluorescence Detection and Cellular Imaging of O-GlcNAc-Modified Proteins," J. Am. Chem. Soc. 2008, 130, 11576–11577.

Murrey, H. E.; Hsieh-Wilson, L. C. "The Chemical Neurobiology of Carbohydrates," Chem. Rev. 2008, 108, 1708–1731.

Rexach, J. E.; Clark, P. M.; Hsieh-Wilson, L. C. "Chemical Approaches to Understanding O-GlcNAc Glycosylation in the Brain," Nature Chem. Biol. 2008, 4, 97–106.

Rawat, M.; Gama, C . I.; Matson, J. B.; Hsieh-Wilson, L. C. "Neuroactive Chondroitin Sulfate Glycomimetics," J. Am. Chem. Soc. 2008, 130, 2959–2961. Featured in Chem. Eng. News. 2009, 87, 28.

Sotogaku, N.; Tully, S. E.; Gama, C. I.; Higashi, H.; Tanaka, M.; Hsieh-Wilson, L. C.; Nishi, A., "Activation of Phospholipase C Pathways by Synthetic Chondroitin Sulfate-E Tetrasaccharide Promotes the Neurite Outgrowth of Dopaminergic Neurons," J. Neurochem. 2007, 103, 749–760.

Khidekel, N.; Ficarro, S. B.; Clark, P. M.; Bryan, M.; Swaney, D. L.; Rexach, J.; Sun, Y. E.; Coon, J. J.; Peters, E. C; Hsieh-Wilson, L. C. "Probing the Dynamics of O-GlcNAc Glycosylation in the Brain using Quantitative Proteomics," Nature Chem. Biol. 2007, 3, 339–348. Featured in Nature Chem. Biol. 2007, 3, 303–304 and Nature 2007, 447, 510–511.

Boeggeman, E.; Ramakrishnan, B.; Kilgore, C.; Khidekel, N.; Hsieh-Wilson, L. C.; Simpson, J. T.; Qasba P. K. "Direct Identification of Nonreducing GlcNAc Residues on N-Glycans of Glycoproteins Using a Novel Chemoenzymatic Method," Bioconjug. Chem. 2007, 18, 806–814.

Shipp, E. L.; Hsieh-Wilson, L. C. "Profiling the Sulfation Specificities of Glycosaminoglycan Interactions with Growth Factors and Chemotactic Proteins Using Microarrays," Chem. Biol. 2007, 14, 195–208. Featured in Chem. Biol. 2007, 14, 119–120.

Hsieh-Wilson, L. C. "A Sweet Synthesis," Nature 2007, 445, 31–33.

Gama, C. I.; Tully, S. E.; Sotogaku, N.; Clark, P. M.; Rawat, M.; Vaidehi, N.; Goddard, W. A., III; Nishi, A.; Hsieh-Wilson, L. C. "Sulfation Patterns of Glycosaminoglycans Encode Molecular Recognition and Activity," Nature Chem. Biol. 2006, 2, 467–473. Featured in Nature Chem. Biol. 2006, 2, 449–450, Nature Methods 2006, 3, 769, and Chem. Eng. News 2006, 84, 48.

Tully, S. E.; Rawat, M.; Hsieh-Wilson, L. C. "Discovery of a TNF-α Antagonist Using Chondroitin Sulfate Microarrays," J. Am. Chem. Soc. 2006, 128, 7740–7741.

Murrey, H.; Gama, C. I.; Kalovidouris, S. A.; Luo, W.-I.; Hsieh-Wilson, L. C. "Protein Fucosylation Regulates Synapsin Ia/Ib Expression and Neuronal Morphology in Primary Hippocampal Neurons," Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 21–26. Featured in "This Week in PNAS," Sci. STKE 2006, 472, 317 and Nature Chem. Biol. 2006, 2, 67.

Gama, C. I.; Hsieh-Wilson, L. C. "Chemical approaches to deciphering the glycosaminoglycan code," Curr. Op. Chem. Biol. 2005, 9, 609–619.

Kalovidouris, S.; Gama, C. I.; Hsieh-Wilson, L. C. "A Role for Fucose α(1-2) Galactose Carbohydrates in Neuronal Growth," J. Am. Chem. Soc. 2005, 127, 1340–1341.

Khidekel, N.; Ficarro, S. B.; Peters, E. C; Hsieh-Wilson, L. C. "Exploring the O-GlcNAc Proteome: Direct Identification of O-GlcNAc-Modified Proteins," Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 13132–13137. Featured in Nature Methods 2004, 1, 5.

Hsieh-Wilson, L. C. "Tailor-made Glycoproteins," Trends Biotechnol. 2004, 22, 489–491.

Tai, H.-C.; Khidekel, N.; Ficarro, S. B.; Peters, E. C; Hsieh-Wilson, L. C. "Parallel Identification of O-GlcNAc-Modified Proteins from Cell Lysates," J. Am. Chem. Soc. 2004, 126, 10500–10501.

Tully, S. E.; Mabon, R.; Gama, C. I.; Tsai, S. L.; Liu, X.; Hsieh-Wilson, L. C. "A Chondroitin Sulfate Small Molecule that Stimulates Neuronal Outgrowth," J. Am. Chem. Soc. 2004, 126, 7736–7737. Featured in Chem. Eng. News. 2004, 82, 9.

Khidekel, N.; Hsieh-Wilson, L. C. "A 'Molecular Switchboard' – Covalent Modifications to Proteins and Their Impact on Transcription," Org. Biomol. Chem. 2004, 2, 1–7.

Khidekel, N.; Arndt, S.; Lamarre-Vincent, N.; Lippert, A.; Poulin-Kerstien, K. G.; Ramakrishnan, B.; Qasba, P. K.; Hsieh-Wilson, L. C. "A Chemoenzymatic Approach Toward the Rapid and Sensitive Detection of O-GlcNAc Posttranslational Modifications," J. Am. Chem. Soc. 2003, 125, 16162–16163.

Arndt, S. E.; Hsieh-Wilson, L. C. "Use of Cerny Expoxides for the Accelerated Synthesis of Glycosaminoglycans," Org. Lett. 2003, 5, 4179–4182.

Lamarre-Vincent, N.; Hsieh-Wilson, L. C. "Dynamic Glycosylation of the Transcription Factor CREB: A Potential Role in Gene Regulation," J. Am. Chem. Soc. 2003, 125, 6612–6613. Featured in Chem. Eng. News 2003, 81, 21.