Introduction to Glycosaminoglycans

Glycosaminoglycans (GAGs) are a family of sulfated sugar chains that play important roles in neuronal communication by binding to different proteins.  Subtle variations in stereochemistry, length, and patterns of sulfation differ between and within GAG families.  This structural diversity creates an enormous number of protein binding motifs.  However, it also has hampered efforts to define the structural and functional properties of GAGs.  

We are developing two general methods for the synthesis of glycosaminoglycans.  Chemical and chemoenzymatic approaches will allow us to synthesize sugar chains with precise control over length, stereochemistry, and sulfation patterns.  Synthetic access to defined GAG structures will allow us to understand their biological roles in the brain.  For example, we will address which GAG structures are important for learning and memory and how changes in sulfation pattern impact aging and neurodegenerative disease.

For more information on the chemistry and biology of GAGs, click here.