Publications
 

"Dynamic Glycosylation of the Transcription Factor CREB: A Potential Role in Gene Regulation," Nathan Lamarre-Vincent and Linda C. Hsieh-Wilson. J. Am. Chem. Soc. 125, 6612-6613 (2003). Abstract  PDF.  Featured in Chem. Eng. News, 81, 21 (2003)

"Use of Cerny Expoxides for the Accelerated Synthesis of Glycosaminoglycans," Sabine Arndt and Linda C. Hsieh-Wilson, Org. Lett. 5, 4179-4182 (2003). Abstract  PDF.

"A Chemoenzymatic Approach Toward the Rapid and Sensitive Detection of O-GlcNAc Posttranslational Modifications," Nelly Khidekel, Sabine Arndt, Nathan Lamarre-Vincent, Alexander Lippert, Katherine G. Poulin-Kerstien, Boopathy Ramakrishnan, Pradman K. Qasba and Linda C. Hsieh-Wilson, J. Am. Chem. Soc. 125,16162-16163 (2003). Abstract  PDF.

"A 'Molecular Switchboard'––Covalent Modifications to Proteins and Their Impact on Transcription," Nelly Khidekel and Linda C. Hsieh-Wilson, Org. Biomol. Chem. 2, 1-7 (2004). Abstract   PDF.

"A Chondroitin Sulfate Small Molecule that Stimulates Neuronal Growth,"  Sarah E. Tully,  Ross Mabon, Cristal Gama, Sherry M. Tsai, Xuewei Liu, and Linda C. Hsieh-Wilson, J Am. Chem. Soc.,126, 7736-7737(2004). Abstract  PDF.  Featured in Chem. Eng. News, 82, 9 (2004)

"Parallel Identification of O-GlcNAc Modified Proteins from Cell Lysates," Hwan-Ching Tai, Nelly Khidekel, Scott B. Ficarro, Eric C. Peters, and Linda C. Hsieh-Wilson, J. Am. Chem. Soc., 126, 10500-1 (2004).  Abstract  PDF.

"Exploring the O-GlcNAc Proteome:  Direct Identification of O-GlcNAc-Modified Proteins," Nelly Khidekel, Scott B. Ficarro, Eric C. Peters, and Linda C. Hsieh-Wilson, Proc. Natl. Acad. Sci. U.S.A.,  36, 13132-7 (2004). Abstract PDF.

"Tailor-made Glycoproteins," Linda C. Hsieh-Wilson, Trends Biotechnol., 22, 489-91 (2004).  PDF.

"A Role for Fucose α(1-2) Galactose Carbohydrates in Neuronal Growth," Stacey Kalovidouris, Cristal Gama, Lori Lee, and Linda C. Hsieh-Wilson,  J. Am. Chem. Soc., 127, 5, 1340-1 (2005). Abstract  PDF

"Chemical Approches to Deciphering the Glycosaminoglycan Code," Cristal I. Gama, and Linda C. Hsieh-Wilson,  Curr. Op. Chem. Biol., 9, 609-619 (2005). Abstract PDF

"Protein Fucosylation Regulates Synapsin Ia/Ib Expression and Neuronal Morphology in Primary Hippocampal Neurons," Heather Murrey, Cristal I. Gama, Stacey A. Kalovidouris,  Wen-I Luo, Edward M. Driggers, Barbara Porton, and Linda C.Hsieh-Wilson, Proc. Natl. Acad. Sci. U.S.A., 103, 1, 21-26 (2006). Abstract  PDF.  Featured in Nature Chem. Biol. 2, 67-68 (2006), Sci. STKE, and PNAS.

"Discovery of a TNFα Antagonist Using Chondroitin Sulfate Microarrays,"  Sarah E. Tully, Manish Rawat, and Linda C. Hsieh-Wilson, J. Am. Chem. Soc. 128, 24, 7740-7741 (2006). Abstract  PDF

"Sulfation Patterns of Glycosaminoglycans Encode Molecular Recognition and Activity," Cristal I. Gama, Sarah E. Tully, Naoki Sotogaku, Peter M. Clark, Manish Rawat, Nagarajan Vaidehi, William A. Goddard III, Akinori Nishi, & Linda C. Hsieh-Wilson, Nature Chem. Biol. 2, 9, 467-473 (2006). Abstract  PDF.  Featured in  Nature Chem. Biol. 2, 449-450 (2006), Nature Methods, and C&E News.

"Profiling the Sulfation Specificities of Glycosaminoglycan Interactions with Growth Factors and Chemotactic Proteins Using Microarrays." Eric L. Shipp and Linda C. Hsieh-Wilson, Chem. Biol., 14, 195-208 (2007).  Abstract  PDF. Featured in Chem. Biol. 14, 119 (2007). 

"Probing the Dynamics of O-GlcNAc Glycosylation in the Brain using Quantitative Proteomics." Nelly Khidekel, Scott B. Ficarro, Peter M. Clark, Marian C. Bryan, Danielle L. Swaney, Jessica E. Rexach, Yi E. Sun, Joshua J. Coon, Eric C. Peters & Linda C. Hsieh-Wilson, Nature Chem. Biol. 3, 6, 339-48 (2007).  Abstract  PDF.  Featured on the journal cover, in Nature Chemical Biology News and Views, and in Nature Research Highlights.

 "A Sweet Synthesis." Linda C. Hsieh-Wilson, Nature, 445, 31-33 (2007).  PDF.

"Direct Identification of Nonreducing GlcNAc Residues on N-Glycans of Glycoproteins Using a Novel Chemoenzymatic Method."  Elizabeth Boeggeman, Boopathy Ramakrishnan, Charlton Kilgore, Nelly Khidekel, Linda C. Hsieh-Wilson, John T. Simpson, and Pradman K. Qasba, Bioconjug Chem. 18, 806-814 (2007).  Abstract PDF.

"Activation of Phospholipase C Pathways by Synthetic Chondroitin Sulfate-E Tetrasaccharide Promotes the Neurite Outgrowth of Dopaminergic Neurons," Naoki Sotogaku, Sarah E. Tully, Cristal I. Gama, Hideho Higashi, Masatoshi Tanaka, Linda C. Hsieh-Wilson, Akinori Nishi, J. Neurochem. 103, 749-760 (2007).  Abstract PDF.

"Chemical Approaches to Understanding O-GlcNAc Glycosylation in the Brain." Jessica E. Rexach, Peter M. Clark, Linda C. Hsieh-Wilson, Nature Chem. Biol. 4, 2, 97-106 (2008).  Abstract PDF.

"Neuroactive Chondroitin Sulfate Glycomimetics," Manish Rawat, Cristal I. Gama, John B. Matson, and Linda C. Hsieh-Wilson, J. Am. Chem. Soc. 130, 10, 2959-61 (2008).  Abstract PDF.

"The Chemical Neurobiology of Carbohydrates," Heather E. Murray, Linda C. Hsieh-Wilson, Chem. Rev. 108, 5, 1708-31 (2008). PDF.

"Direct In-Gel Fluorescence Detection and Cellular Imaging of O-GlcNAc-Modified Proteins," Peter M. Clark, Jessica F. Dweck, Daniel E. Mason, Courtenay R. Hart, Suzanne B. Buck, Eric C. Peters, Brian J. Agnew, and Linda C. Hsieh-Wilson, J. Am. Chem. Soc. (2008).  Abstract PDF.

"Site-Specific GlcNAcylation of Human Erythrocyte Proteins: Potential Biomarker(s) for Diabetes Mellitus," Wang Z.; Park K; Comer F.; Hsieh-Wilson, L.C.; Saudek, C.D., Hart, G.W. Diabetes, 58, 309-317 (2009).  Abstract PDF. 

"Identification of the Plasticity-Relevant Fuca(1-2)Gal Proteome from Mouse Olfactory Bulb,"  Murrey, H. E.; Ficarro, S.; Peters, E.; Hsieh-Wilson, L. C., Biochemistry, in press.

"Controlling Chemical Reactivity with Antibodies," Linda C. Hsieh, Shirlee Yonkovich, Lynn Kochersperger, and Peter G. Schultz. Science 260, 337-339 (1993).

"Progress Toward an Antibody Glycosidase," Jaehoon Yu, Linda C. Hsieh, Lynn Kochersperger, Shirlee Yonkovich, James C. Stephans, Mark A. Gallop, and Peter G. Schultz. Angew. Chem. Int. Ed. Engl.33, 339-340 (1994).

"An Efficient Antibody-Catalyzed Oxygenation Reaction," Linda C. Hsieh, James C. Stephans, and Peter G. Schultz. J. Am. Chem. Soc. 116, 2167-2168 (1994).

"Lessons from the Immune System: From Catalysis to Materials Science," Linda C. Hsieh-Wilson, Xiao-Dong Xiang, and Peter G. Schultz. Acc. Chem. Res. 29, 164-170 (1996).

"Insights into Antibody Catalysis: Structure of an Oxygenation Catalyst at 1.9-Å Resolution," Linda C. Hsieh-Wilson, Peter G. Schultz, and Raymond C. Stevens. Proc. Natl. Acad. Sci. USA 93, 5363-5367 (1996).

"Antibody Catalysis of Peptidyl-Prolylcis-trans Isomerization in the Folding of RNase T1," Lifu Ma, Linda C. Hsieh-Wilson, and Peter G. Schultz. Proc. Natl. Acad. Sci. USA 95, 7251-7256 (1998).

"Protein Phosphatase 1 Modulation of Neostriatal AMPA Channels: Regulation by DARPP-32 and Spinophilin," Zhen Yan, Linda Hsieh-Wilson, Jian Feng, Kazuhito Tomizawa, Patrick B. Allen, Allen A. Fienberg, Angus C. Nairn, and Paul Greengard. Nature Neurosci. 2, 13-17 (1999).

"Characterization of the Neuronal Targeting Protein Spinophilin and Its Interactions with Protein Phosphatase-1," Linda C. Hsieh-Wilson, Patrick B. Allen, Takuo Watanabe, Angus C. Nairn, and Paul Greengard. Biochemistry 38, 4365-4373 (1999).

"Protein Phosphatase 1 Regulation by Inhibitors and Targeting Subunits," Takuo Watanabe, Hsien-bin Huang, Atsuko Horiuchi, Linda C. Hsieh-Wilson, Patrick B. Allen, Shirish Shenolikar, Paul Greengard, Angus C. Nairn. Proc. Natl. Acad. Sci. USA 98, 3080-3085 (2001).

"The Actin-Binding Domain of Spinophilin is Necessary and Sufficient for Targeting to Dendritic Spines," Stacie D. Grossman, Linda C. Hsieh-Wilson, Patrick B. Allen, Angus C. Nairn, Paul Greengard. NeuroMolec. Medicine 2, 45-54 (2002).

"Phosphorylation of Spinophilin Modulates Its Interaction with Actin Filaments," Linda C. Hsieh-Wilson, Fabio Benfenati, Patrick B. Allen, Gretchen L. Snyder, Angus C. Nairn, Paul Greengard. J. Biol. Chem. 278, 1186-1194 (2003).

"Spinophilin is phosphorylated by Ca²⁺/calmodulin-dependent protein kinase II resulting in regulation of its binding to F-actin, " Stacie D. Grossman, Marie Futter, Gretchen L. Snyder, Patrick B. Allen, Angus C. Nairn, Paul Greengard, Linda C. Hsieh-Wilson, J. Neurochem. 90, 317-324 (2004).