Overview

We are interested in understanding and controlling assemblies of dynamically interacting biological molecules, in real time. In particular, we are interested in the diverse class of biological functions involved in information transfer. For example, we want to learn how collective effects at the molecular level ultimately result in complex and coordinated behavior displayed by signaling pathways and other biochemical reaction networks that are essential to cellular functioning, such as signal amplification. As a means toward achieving this goal, we are developing new tools that are combinations of single-molecule fluorescence spectroscopy, microfluidics, and scanning probe microscopy.